Dana Farber Cancer Institute

Boston, Massachusetts

To meet the growing needs of its research program, the Dana Farber Cancer Institute has constructed a new building for cancer and other bio-medical research.

The project required the construction of a thirteen-story structure above grade and a seven-level, vibration-dampening parking garage below grade.

The first floor houses the entry lobby, coffee shop, loading and receiving areas and mechanical space. Offices and workspace for epidemiological research are located on the second floor. General research support and administrative functions are on the third floor. The fourth floor provides mechanical space. Floors five through thirteen house generic research laboratories.

Alnylam Pharmaceuticals Lab Conversion

Cambridge, MA

Alnylam is a biopharmaceutical company developing novel therapeutics based on a breakthrough in biology known as RNA interference, or RNAi; a discovery that enables the creation of a broad new class of human therapeutics.

Perini converted 45,000 square feet of office space to research laboratories, designed by ADD Inc and AHA Consulting Engineers for Alnylam Pharmaceuticals / Palm, Inc. / Beal Companies.

AstraZeneca Pharmaceuticals

Westborough, Massachusetts

Perini has built several production line expansions for AstraZeneca at its Westborough, Mass. facility. Good Manufacturing Practice (or GMP) established by the U.S. Food and Drug Administration requires an extremely high level of quality assurance to minimize or eliminate the possibility of contamination.

All ductwork for example, must be cleaned and sealed at the factory and cleaned once again following installation. Connecting joints in process piping are flouroscoped to ensure the integrity of the welds.

300 Third Street

Cambridge, Massachusetts

Conveniently located in the heart of Kendall Square in Cambridge, MA -- a rapidly-growing center for biotech and commerce -- the 130,000-square-foot office and laboratory development of The Beal Companies, LLP is setting a high standard for design and construction of structures that are currently on the drawing boards or under construction in the area.

With four levels of Class A office and laboratory space, 300 Third Street places great emphasis on its distinctive tenant amenities including a 2,000-square-foot lobby with accessory retail space, two-levels of enclosed parking for 150 vehicles and landscaped courtyard.

MIT Lincoln Laboratories

Lexington, Massachusetts

MIT's South Laboratories is a four-story structure with a full basement. Laboratory and office space is located on all four floors, common spaces will be located at convenient locations.

Service corridors are provided throughout the four technical floors so as to separate staff corridors from service functions. Major utility spaces are located in the basement.

There is also a new four-story parking garage accommodating 870 cars with a connecting corridor to the South Lab.

Argonne National Laboratory, University of Chicago

Argonne, Illinois

The design/build project for a 200,000-square-foot chemistry facility contains research and teaching laboratories, faculty offices, a 150-seat lecture hall, classrooms, support space and administrative offices.

Cornell University Veterinary Hospital

Ithaca, New York

The five-story 300,000-square-foot facility houses hospital services on the first two floors with admitting, operating rooms, intensive care, x-ray, exam, etc.

Research areas on the upper levels contain laboratories, environmental space, offices and support functions.